Description

Semax Research Topics:

1. Neuroprotection and Neurorestoration:

   Semax upregulates Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), which are crucial for neuron survival, development, and function. This results in enhanced neuroprotection and neurorestoration, particularly beneficial for conditions like ischemic stroke. (PMID: 16996037)

2. Cognitive Enhancement:

   Semax improves cognitive functions such as memory, learning, and mental clarity. Its nootropic effects are linked to increased levels of neurotransmitters and neurotrophins in the brain. (PMID: 16996037)

3. Mood Improvement:

   By modulating the activity of neurotransmitters like serotonin and dopamine, Semax helps regulate mood and reduce symptoms of depression and anxiety. (PMID: 28702721)

4. Immunomodulation:

   Semax has immunomodulatory properties, influencing the balance of pro-inflammatory and anti-inflammatory cytokines, which can enhance immune response and reduce inflammation. (PMID: 31028579)

Peer-Reviewed Studies 

• The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax. Serdiuk, A. V., Levitskiĭ, G. N., Miasoedov, N. F., & Skvortsova, V. I. (2007). S.S. Korsakova, 107(4), 29–39.

• Semax, a synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Glazova, N. Y., Manchenko, D. M., Volodina, M. A., Merchieva, S. A., Andreeva, L. A., Kudrin, V. S., Myasoedov, N. F., & Levitskaya, N. G. (2021). Neuropeptides, 86, 102114. https://doi.org/10.1016/j.npep.2020.102114

Structure

Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro

Molecular Formula: C39Hs4N10010S

Molecular Weight 854.99 g/mol

PubChem CID: 122178

CAS Number: 80714-61-
Synonyms: Pro-Gly-Pro-ACTH