Description

PT-141 Research Topics:

1. PT-141 is effective in treating sexual dysfunction in both men and women. It increases sexual desire and arousal by activating melanocortin receptors in the brain, which enhances blood flow to the sexual organs and improves sexual performance. (PMID: 12851303)

2. Alternative to PDE5 Inhibitors:

   PT-141 is a viable alternative for those who do not respond well to phosphodiesterase type 5 inhibitors (PDE5i) like sildenafil (Viagra) or tadalafil (Cialis). It works through a different mechanism, offering a solution for those who experience side effects from or have contraindications to PDE5i. (PMID: 14999221)

Peer-Reviewed Studies

• Bremelanotide for the treatment of hypoactive sexual desire disorder: two randomized phase 3 trials.

Kingsberg, S. A., Clayton, A. H., Portman, D., Williams, L. A., Krop, J., Jordan, R., … & Simon, J. A. (2019). Obstetrics and gynecology, 134(5), 899.

• WOMEN’S SEXUAL HEALTH: An Effect on the Subjective Sexual Response in Premenopausal Women with Sexual Arousal Disorder by Bremelanotide (PT‐141), a Melanocortin Receptor Agonist.

Diamond, L. E., Earle, D. C., Heiman, J. R., Rosen, R. C., Perelman, M. A., & Harning, R. (2006). The journal of sexual medicine, 3(4), 628-638.

Structure

Sequence: Ac-Nle-Asp(l)-His-D-Phe-Arg-Trp­Lys(l)
Molecular Formula: C50H6aN14O10
Molecular Weight: 1025.182 g/mol
PubChem CID: 9941379
CAS Number: 189691-06-3