Description

DSIP improves sleep, reduces stress, and has analgesic properties, making it beneficial for sleep disorders, stress management, and pain relief. (PMID: 16539679, PMID: 6145137, PMID: 1530226)

Delta Sleep-Inducing Peptide (DSIP) Research Topics:

1. Sleep Regulation:

   DSIP is primarily known for its ability to induce and improve sleep by interacting with sleep-regulating systems in the brain. (PMID: 16539679)

2. Stress Reduction:

   It has been shown to modulate stress response and reduce stress-related symptoms, potentially by influencing cortisol levels. (PMID: 6145137)

3. Pain Relief:

   DSIP may have analgesic properties, contributing to pain relief in various conditions. (PMID: 1530226)

Peer-Reviewed Studies 

• DSIP-Like KND Peptide Reduces Brain Infarction in C57Bl/6 and Reduces Myocardial Infarction in SD Rats When Administered during Reperfusion. Tukhovskaya, E. A., Shaykhutdinova, E. R., Ismailova, A. M., Slashcheva, G. A., Prudchenko, I. A., Mikhaleva, I. I., Khokhlova, O. N., Murashev, A. N., & Ivanov, V. T. (2021). Biomedicines, 9(4), 407. https://doi.org/10.3390/biomedicines9040407

• Phosphorylated delta sleep-inducing peptide restores spatial memory and p-CREB expression by improving sleep architecture at high altitudes. Roy, K., Chauhan, G., Kumari, P., Wadhwa, M., Alam, S., Ray, K., Panjwani, U., & Kishore, K. (2018). Life sciences, 209, 282–290. https://doi.org/10.1016/j.lfs.2018.08.026

Structure

Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu Molecular Formula: C35H4aN10015 
Molecular Weight: 848.824 g/mol 
PubChem CID: 68816 
CAS Number: 62568-57-4 
Synonyms: Emideltide, DSIP nonapeptide, Deltaran

Source: PubChem

Referenced Citations

1. “The influence of synthetic DSIP (delta-sleep-­inducing-peptide) on disturbed human sleep I Springerlink.” [Online]. Available: 
   https://link.springer.com/article/10.10072FB F01971753. [Accessed: 25-Jun-2019]. 
2. “Effects of the delta-sleep-inducing peptide on 24-hour sleep-wake behavior in severe chronic insomnia. – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/Rubmed/362258 _g. [Accessed: 25-Jun-2019].
3.  “Effects of delta sleep-inducing peptide on the sleep of chronic insomniac patients. A double­blind study. – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/Rubmed/129979 1- [Accessed: 25-Jun-2019].
4.  “Acute and delayed effects of DSIP (delta sleep-inducing peptide) on human sleep behavior. – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/6895513– [Accessed: 25-Jun-2019].
5. “Therapeutic effects of delta-sleep-inducing peptide (DSIP) in patients with chronic, pronounced pain episodes. A clinical pilot study. – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/6548970. [Accessed: 25-Jun-2019].
6. “Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP). – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/2853064- [Accessed: 25-Jun-2019].
7. “Delta sleep-inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress-protective potency under experimental hypo … – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/12668217. [Accessed: 25-Jun-2019].
8. “Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress. – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/7628639. [Accessed: 25-Jun-2019].
9. “Decreased concentrations of delta-sleep inducing peptide in plasma and cerebrospinal fluid from depressed patients: Nordisk Psykiatrisk Tidsskrift: Vol 39, No sup11.” [Online]. Available: https://www.tandfonline.com/doi/abs/10.3109/08039488509101959. [Accessed: 25-Jun-2019].
10. “Delta sleep-inducing peptide (DSIP): An overview of central actions and possible relationship to psychiatric illnesses: Nordisk Psykiatrisk Tidsskrift: Vol 42, No 2.” [Online]. Available: https://www.tandfonline.com/doi/abs/10.3109/ 08039488809103215. [Accessed: 25-Jun-2019].
11. “High delta sleep-inducing peptide-like immunoreactivity in plasma in suicidal patients with major depressive disorder. -PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/9606527. [Accessed: 25-Jun-2019].
12. “Opioid detoxification with delta sleep­-inducing peptide: results of an open clinical trial. – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/Rubmed/9617990. [Accessed: 25-Jun-2019].
13. “DSIP in the treatment of withdrawal syndromes from alcohol and opiates. -PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/Rubmed/6548969– [Accessed: 25-Jun-2019].
14. “Effect of delta-sleep inducing peptide­-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female … – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/pubmed/12782416. [Accessed: 25-Jun-2019].
15. E. V. Koplik et al., “Delta sleep-inducing peptide and Deltaran: potential approaches to anti-stress protection,” Neurosci. Behav. Physiol., vol. 38, no. 9, pp. 953-957, Nov. 2008.
16. “[DSIP: the sleep peptide or an unknown hypothalamic hormone?]. – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/Rubmed/7817664– [Accessed: 25-Jun-2019].
17. “DSIP–a tool for investigating the sleep onset mechanism: a review”. – PubMed – NCBI.” [Online]. Available: https://www.ncbi.nlm.nih.gov/Rubmed/3286557. [Accessed: 25-Jun-2019].
18. Shlomo Yehuda & Ralph L. Carasso (1987) The Effects of Dsip on Pain Threshold During Light and Dark Periods in Rats are not Naloxone- Sensitive, International Journal of Neuroscience, 37:1-2, 85- 88, DOI: 10.3109/00207458708991805
19. Graf, Markus & Christen, Heinz & Schoenenberger, Guido. (1982). DSIP/DSIP­ and circadian motor activity of rats under continuous light. Peptides. 3. 623-6. 10.1016/0196-9781(82)90161-9.
20. Shlomo Yehuda & Ralph L. Carasso (1988) Dsip-a Tool for Investigating the Sleep Onset Mechanism: A Review, International Journal of Neuroscience, 38:3-4, 345- 353, DOI: 10.3109/00207458808990695
21. Yehuda, S., Kastin, A.J. and Coy, D.H. (1980). Thermoregulatory and locomotor effects of DSIP: Paradoxical interaction with d-amphetamine. Pharmacology Biochemistry and Behavior, [online] 13(6), pp.895-900. Available at: https://www.sciencedirect.com/science/article/ Rii/0091305780902257