Description

Chonluten, a bioregulatory peptide, enhances lung health by reducing inflammation and stabilizing mucosal function, provides anti-inflammatory and antioxidant effects by regulating genes associated with antioxidant enzymes and inflammatory mediators, and supports gastrointestinal health by promoting mucosal regeneration and reducing inflammation. (PMID: 22803148, PMID: 35408963 )​

Chonluten Research Topics:

1. Lung Health:

   Chonluten regulates gene expression in the lungs, helping to reduce inflammation and stabilize mucosal function, which is particularly beneficial for conditions like chronic obstructive pulmonary disease (COPD) and asthma. It normalizes mucus secretion and improves the extracellular matrix structure, aiding in respiratory health. (PMID: 22803148)​ 

2. Anti-Inflammatory and Antioxidant Effects:

   Chonluten has been shown to regulate genes associated with antioxidant enzymes and inflammatory mediators, such as superoxide dismutase (SOD) and TNF-alpha. This helps reduce oxidative stress and inflammation, promoting cell regeneration and tissue repair in both the lungs and gastrointestinal tract. (PMID: 35408963)​ 

3. Gastrointestinal Health:

   The peptide’s ability to modulate gene expression also extends to the gastrointestinal tract, where it can reduce inflammation and promote the regeneration of the gastric mucosa. This makes it useful for managing conditions like Crohn’s disease and ulcerative colitis. (PMID: 22803148)​ 

Structure

Molecular Formula: C11H11N30a 
Molecular Weight: 319.27 g/mol 
PubChem CID: 194641 
CAS No: 75007-24-8 
Alternative Names: T-34 tripeptide, EDG

Source: PubChem 

Tripeptides in Bioregulation

A number of small di-, tri-, and tetrapeptides have been shown to increase life span by as much as 40% in animal studies. They appear to do this in several ways, such as suppressing the development of both spontaneous and induced tumors. This fact, combined with a reduction in the rate at which age-related biomarkers decline, has led scientists to postulate that some tripeptides may regulate gene expression as well as cellular processes like apoptosis [2],[3]. 

Research indicates that short peptides can regulate all aspects of gene expression, including epigenetic DNA methylation [4]. Modeling studies have shown that a single short peptide can regulate dozens of genes by penetrating both cytoplasmic (cell) and nuclear membranes to bind directly to DNA via a simple docking method at the promoter, suppressor, and other DNA control regions [5]. 

Given the extensive role that Russia has played over the decades in the isolation and development of peptides and peptide bioregulators, it should come as no surprise that the leading authority on Chonluten is Vladimir Khavinson. Dr. Khavinson is the current director of the St. Petersburg Institute of Bioregulation and Gerontology and has served on several international committees focused on geriatrics and gerontology. His works have made it clear that Chonluten and other short peptides can bind directly to DNA to produce their effects. Dr. Khavinson indicates that Chonluten is just one of many short peptides that are ushering in a new way of approaching both health and disease as we age. 

Chonluten and the Lungs 

Chonluten appears to have tissue-specific activity in the lungs, altering DNA expression in a way that normalizes mucosa in the bronchi. This inner lining of the bronchi is the barrier between the outside world that we inhale with every breath and the inner workings of our cardiovascular system and, ultimately, our entire body. It can be altered via different inflammatory conditions, such as asthma or COPD, in ways that lead to changes in mucus production, extracellular matrix structure, and more. Smoker’s cough, for instance, is an inflammatory condition that leads to chronic irritation of the mucosal lining and subsequent chronic cough, phlegm production, and more. 

Chonluten’s effects appear to be mediated through several genes including c-Fos, heat shock protein gene HSP70, SOD, COX-2, TNF-alpha, and genes within the antioxidant system. Regulation of most of these genes has obvious anti-inflammatory effects. Of particular interest, however, is c-FOS. The c-FOS protein is a potent general regulator of cell proliferation, differentiation, and survival. It is activated in response to cellular damage and hypoxia. While its effects at a local level can be useful, such as the growth of new blood vessels and the proliferation of cells following injury, widespread expression can lead to thickened bronchial mucosa and even the development of cancer. The ability to regulate c-FOX activity offers the ability to strike one of the underlying pathophysiological changes seen in asthma and COPD [1]. 

Chonluten and COVID-19 

 A peptide with active anti-inflammatory effects is of obvious interest to scientists during the global COVID-19 pandemic. Research shows that Chonluten and its similar cousin Bronchogen are effective for the treatment of bronchopulmonary pathology. Chonluten appears to improve the effectiveness of standard therapy in the setting of chronic bronchitis with an asthmatic component and has stress-­protective effects. Both of these features, combined with the fact that Chonluten improves physical performance and organism function state in the setting of low oxygen, might make this tripeptide a useful adjuvant in a multi-component cocktail for fighting COVID-19 [7]. 

Chonluten and the GI Tract 

The effects of Chonluten in the GI tract are similar if muted, to its effects in the lungs. Research suggests that it may be useful in reducing inflammation and vascular changes in the GI tract that result from inflammatory diseases like Crohn’s disease and ulcerative colitis. Research on this aspect of Chonluten is ongoing [1]. 

Chonluten Summary 

Chonluten is a short peptide regulator of gene expression. It appears to be most active in lung tissue with secondary levels of activity in the GI tract. It regulates genes related to inflammation and antioxidant activity as well as genes involved in proliferation responses to inflammation. Regulation of pulmonary mucosal function by Chonluten may have important applications in chronic inflammatory diseases of the lung such as asthma. 

Chonluten exhibits minimal side effects and low oral and excellent subcutaneous bioavailability in mice. Per kg, dosage in mice does not scale to humans. Chonluten for sale at Life Link Research is limited to educational and scientific research only, not for human consumption. Only buy Chonluten if you are a licensed researcher. 

Article Author

The above literature was researched, edited, and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate from Case Western Reserve University School of Medicine and a B.S. in molecular biology. 

Scientific Journal Author 

Vladimir Khavinson is a Professor, resident of the European region of the International Association of Gerontology and Geriatrics; Member of the Russian and Ukrainian Academies of Medical Sciences; Main gerontologist of the Health Committee of the Government of Saint Petersburg, Russia; Director of the Saint Petersburg Institute of Bioregulation and Gerontology; Vice ­president of Gerontological Society of the Russian Academy of Sciences; Head of the Chair of Gerontology and Geriatrics of the North-Western State Medical University, St-Petersburg; Colonel of medical service (USSR, Russia), retired. Vladimir Khavinson is known for the discovery, experimental, and clinical studies of new classes of peptide bioregulators as well as for the development of bioregulating peptide therapy. He is engaged in studying the role of peptides in the regulation of the mechanisms of ageing. His main field of action is the design, pre-clinical, and clinical studies of new peptide geroprotectors. A 40-year­ investigation resulted in a multitude of methods of application of peptide bioregulators to slow down the process of aging and increase human life span. Six peptide-based pharmaceuticals and 64 peptide food supplements have been introduced into clinical practice by V. Khavinson. He is an author of 196 patents (Russian and international) as well as of 775 scientific publications. His major achievements are presented in two books: “Peptides and Ageing” (NEL, 2002) and “Gerontological Aspects of Genome Peptide Regulation” (Karger AG, 2005). Vladimir Khavinson introduced the scientific specialty “Gerontology and Geriatrics” in the Russian Federation on the governmental level. Academic Council headed by V. Khavinson has oversight over 200 Ph.D. and Doctorate theses from many different countries. 

Prof. Vladimir Khavinson is being referenced as one of the leading scientists involved in the research and development of Chonluten. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Life Link Research and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Prof. Vladimir Khavinson is listed in [1] [2] [4] [5] [6] and [7] under the referenced citations. 

Referenced Citations 

1. V. K. Khavinson, N. S. Lin’kova, A. V. Dudkov, V. 0. Polyakova, and I. M. Kvetnoi,
   “Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins,” Bull. Ex.. Biol. Med., vol. 152, no. pp. 615-618, Mar. 2012, doi:  10.1007 ls10517-012-1590-2.
2. V. N. Anisimov and V. K. Khavinson, “Peptide bioregulation of aging: results and prospects,” Biogerontology, vol. 11, no. 2, pp. 139-149, pr. 2010, doi: 10.1007ls10522-009-9249-8.
3. M.A. Voicekhovskaya, N. I. Chalisova, E. A. Kontsevaya, and G. A. Ryzhak, “Effect of bioregulatory tripeptides on the culture of skin cells from young and old rats,” Bull. Exp.. Biol. Med., vol. 152, no. 3, pp. 357-359, Jan. 2012, doi: 10.1007ls10517-012-1527-9.
4. V. K. Khavinson, I. G. Popovich, N. S. Linkova, E. S. Mironova, and A. R. llina, “Peptide Regulation of Gene Expression: A Systematic Review,” Molecules, vol. 26, no. 22, p. 7053, Nov. 2021, doi: 10.3390lmolecules26227053.
5. V. K. Khavinson, N. S. Lin’kova, and S. I. TarnovskaY.a “Short Peptides Regulate Gene Expression,” Bull. Exp.- Biol. Med., vol. 162, no. 2, pp. 288-292, Dec. 2016, doi: 10.1007 ls10517-016-3596-7.
6. L. I. Fedoreyeva, I. I. Kireev, V. K. Khavinson, and B. F. Vanyushin, “Penetration of short fluorescence-labeled peptides into the nucleus in Hela cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.” Biochem. Biokhimfia, vol. 76, no. 11, Art. no. 11, Nov. 2011, doi: 10.1134IS0006297911110022. 
7. V. Khavinson, N. Linkova, A. Dyatlova, B. Kuznik, and R. Umnov, “Peptides: Prospects for Use in the Treatment of COVID-19: Molecules, vol. 25, no. 19, R· 4389, Sep 2020, doi: 10.3390l molecules25194389.